CHIR99021, GSK3 inhibitor from Abcam

Product Specs
ItemCHIR99021, GSK3 inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120890
Quantity1 mg, 5 mg
TypeInhibitor, inhibitor
Molecule NameCHIR99021

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Inhibiting Glycogen Synthase Kinase 3 Suppresses TDP-43-Mediated Neurotoxicity in a Caspase-Dependent MannerMolecular NeurobiologyJanuary 17, 2026Matthew Anthony White, Leon Crowley, Francesca Massenzio, Xingli Li, Michael Niblock, Sara Milani, Michael Philip Coleman, Sami J. Barmada, Jemeen Sreedharanhttp://n2t.net/addgene:16262; RRID:Addgene_16262). The GSK3 inhibitor CHIR99021, CAS: 252917-06−9, was obtained from Abcam (ab120890) and a 100 µM stock in DMSO stored at −20 °C. AZD 1080, CAS: 612487-72−6 was kindly provided by Dr.

(2) Myocardial disarray drives metabolic inefficiency in human cardiomyocytesCommunications biologyOctober 9, 2025Jouve C, Ruiz-Velasco A, Donnarumma E, Le Borgne R, Momken I, Pereira C, Seguret M, Vermersch E, Vimont E, Nemazanyy I, et al.supplement minus insulin (A18956-01 Thermo Fisher Scientific, Waltham, MA, USA) and 6 µM CHIR-99021 (ab120890 Abcam) and maintained in a 5% CO2/air environment for 48 h. The medium was then changed to RPMI-1640/B27

(3) Generation of human iPSC-derived pancreatic organoids to study pancreas development and diseaseF1000ResearchJune 10, 2025Jean-Francois Darrigrand, Abigail Isaacson, Francesca Maria Spagnoli41400-045) Pen/Strep,Gibco (Cat # 15140122) Activin A (AA),Qkine (Cat # QK001) CHIR-99021 (Chir),Abcam (Cat # ab120890) FGF7,Qkine (Cat # QK046) Vitamin C (Vit. C),Merck (Cat # A4544) Sant1,Merck (Cat # S4572) Retinoic Acid

(4) Inhibiting glycogen synthase kinase 3 suppresses TDP-43-mediated neurotoxicity in a caspase-dependent mannerResearch SquareMay 30, 2025Matthew Anthony White, Leon Crowley, Francesca Massenzio, Xingli Li, Michael Niblock, Michael Philip Coleman, Sami J Barmada, Jemeen SreedharanMutagenesis Kit (Agilent). The GSK3 inhibitor CHIR99021, CAS: 252917–06-9 was obtained from Abcam (ab120890) and a 100μM stock in DMSO stored at −20°C. AZD 1080, CAS:612487–72-6 was kindly provided by Dr Richard

(5) The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in cystic epithelial cells revealing a potential new target for polycystic kidney diseasePLOS GeneticsDecember 12, 2024Abigail O. Smith, William Tyler Frantz, Kenley M. Preval, Yvonne J. K. Edwards, Craig J. Ceol, Julie A. Jonassen, Gregory J. Pazourreplacing medium with STEMdiff APEL2 Medium (Stemcell 05275, ent, WA) containing 8μM CHIR99021 (Abcam ab120890, Cambridge, MA) for four days. The media was replaced with fresh media every two days. On day 5, cells

(6) A Strainer-Based Platform for the Collection and Immunolabeling of Porcine Epidemic Diarrhea Virus-Infected Porcine Intestinal OrganoidInternational Journal of Molecular SciencesOctober 27, 2023Yinju Liu, Jinlong Tan, Nianzhang Zhang, Wenhui Li, Baoquan FuNext, 750 μL was gently added to IntestiCultTM organoid growth medium containing GSK-3 inhibitors (ab120890, Abcam, Cambridge, UK) and ROCK1 inhibitor (A3008, APExBIO Technology LLC, Houston, TX, USA) along the

(7) HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distributionCell ReportsJuly 26, 2022Feng-Chih Kuo, Matt J. Neville, Rugivan Sabaratnam, Agata Wesolowska-Andersen, Daniel Phillips, Laura B.L. Wittemans, Andrea D. van Dam, Nellie Y. Loh, Marijana Todorčević, Nathan Denton, et al.proteins" ,, β-oestradiol,Sigma,E2758 Mifepristone,Sigma,M8046 2-Deoxy-D-glucose,Sigma,D8375 CHIR99021,Abcam,ab120890 ,, Critical commercial assays,Critical commercial assays,Critical commercial assays ,, Luciferase Assay System

(8) RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancerNature communicationsMay 19, 2022Hall AE, Pohl SÖ, Cammareri P, Aitken S, Younger NT, Raponi M, Billard CV, Carrancio AB, Bastem A, Freile P, et al.Matrigel/well) in organoid growth media supplemented with 6 µM CHIR-99021 (GSK-3 inhibitor, Abcam, ab120890). Day 3 – Organoids were further expanded to two full 24-well plates each and grown in ‘Organoid+ media’:

(9) Small Molecule Inhibition of Glycogen Synthase Kinase 3 (GSK-3) Specifically Inhibits the Transcription of Inhibitory Co-Receptor LAG-3 for Enhanced Anti-Tumor ImmunitySSRN Electronic JournalApril 2, 2022Christopher E. Rudd, Kittiphat Chanthong, Alison Taylor6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1Himidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3pyridinecarbonitrile Abcam plc Cat# ab120890 OVA257-264 peptide Bachem Cat# 4053142 OVA Peptide (323-339) GenScript Cat# RP10610 Chemicals,

(10) Mechanosensitive miR-100 coordinates TGFβ and Wnt signaling in osteocytes during fluid shear stressFASEB journal : official publication of the Federation of American Societies for Experimental BiologyOctober 1, 2021Dole NS, Yoon J, Monteiro DA, Yang J, Mazur CM, Kaya S, Belair CD, Alliston T.Wnt3a ligand (50 ng/ml, Peprotech, Cat# 315‐20) or CHIR99021, a GSK3 inhibitor (10 µM, Abcam, Cat# ab120890). Cells were cultured in low serum media (α‐MEM containing 0.5% fetal bovine serum) for 1 h prior to

(11) Derivation and maintenance of mouse haploid embryonic stem cellsNature ProtocolsJuly 1, 2019Ulrich Elling et al.N2B27 medium (StemCells, cat. no. SCS-SF-NB-02). • GSK3 inhibitor: CHIR99021 (CHIR; Abcam, cat. no. ab120890). CAUTION CHIR is acutely toxic if swallowed and an irritant. Consult safety and hazard sheets provided

(12) ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forksNature communicationsJanuary 8, 2019Balmus G, Pilger D, Coates J, Demir M, Sczaniecka-Clift M, Barros AC, Woods M, Fu B, Yang F, Chen E, et al.at day 3, with any eight-cell embryos transferred to KSOM supplemented with CHIR99021 (3 µM; Abcam ab120890) and PD0325901 (1 µM; Sigma PZ0162) for 24 h before being returned to KSOM for further culture to blastocyst.

(13) Economic 3D-printing approach for transplantation of human stem cell-derived β-like cellsBiofabricationDecember 1, 2016Song J, Millman JR.S1 media with 100 ng/ml Activin A (R&D Systems; 338-AC) and 3 PM Chir99021 (only on day 1) (Abcam; ab120890) were added. On days 4 and 5, S2 media with 50 ng/ml KGF (Peprotech; AF-100-19) was added. On day 7,

(14) A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identityNature communicationsJune 15, 2016Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, Berno V, Rossi RL, Reinbold R, Endele M, et al.bFGF (Invitrogen, cat. 13256029); 20 ng ml−1 Activin-A (R&D, cat. 338-AC); 3 μM CHIR99021 (AbCam, cat. ab120890); 1 μM PD 0325901 (Sigma, cat. N°PZ0162); 1 μM EPZ005687 (BioVision, cat. 2364); 2 μM GSK126 (BioVision,

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CHIR99021, GSK3 inhibitor from Abcam

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CHIR99021, GSK3 inhibitor from Abcam

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