Description
Potent and selective inhibitor of CDKs. Selective for CDK1/cyclin B kinase (IC 50 =450nM) [2], CDK2 (IC 50 =700nM) [4] and CDK5/p35 (IC 50 =160nM) [4,5]. More potent than olomoucine (Prod. No. BML-CC200). Inhibits M phase promoting factor (MPF) kinase activity. Has effects on calcium channel gating