Description
Fz7-21 is a peptide antagonist of FZD7. It antagonises WNT3A-induced Wnt-beta-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/beta-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100?nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of beta-catenin in mouse L cells (IC50=50?nM)