Description
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 uM and 32 uM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively