Description
NiCur is a potent and selective CBP histone acetyltransferase (HAT) inhibitor with an IC 50 value of 0.35 µΜ. NiCur, which blocks CBP HAT activity and downregulates p53 activation upon genotoxic stress. NiCur can be used for performing mechanistic studiesIC50& Target:CBP-HAT 0.35 µM (IC 50 )In Vitro:NiCur (0.5~1 µM; U2OS cells) reduces the Dox-induced p53K382ac, p53S15p, and p53 levels in a dose-dependent manner. NiCur (1.5 µM) reduces the level of H3K27ac. NiCur (1.5 µM; U2OS cells) restores cellular proliferation. NiCur (Intestinal epithelialBiological Activity:NiCur is a potent and selective CBP histone acetyltransferase (HAT) inhibitor with an IC 50 value of 0.35 µΜ. NiCur, which blocks CBP HAT activity and downregulates p53 activation upon genotoxic stress. NiCur can be used for performing mechanistic studies