Description
JB061 is a nonmuscle myosin inhibitor with IC 50 s of 4.4 µM ( Cardiac muscle myosin ), 9.1 µM ( Skeletal muscle myosin ), and >100 µM ( Smooth muscle myosin II ), respectively. JB061 poorly decreases ATPase activity ( IC 50 >200 µM). JB061 shows cytotoxiIC50& Target:Cardiac muscle myosin 4.4 µM (IC 50 ) Skeletal muscle myosin 9.1 µM (IC 50 ) Smooth muscle myosin II >100 µM (IC 50 )In Vitro:JB061 (compound 6a) (40 µM; 24 h) inhibits cytokinesis in Cos-7 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Biological Activity:JB061 is a nonmuscle myosin inhibitor with IC 50 s of 4.4 µM ( Cardiac muscle myosin ), 9.1 µM ( Skeletal muscle myosin ), and >100 µM ( Smooth muscle myosin II ), respectively. JB061 poorly decreases ATPase activity ( IC 50 >200 µM). JB061 shows cytotoxi