Description
InformationSW-044248 is a non-canonicalTop1inhibitor with a pattern of selective toxicity for NSCLC cells.TargetsTopo1In vitroSW044248 is selectively toxic for some NSCLC cell lines. SW044248 rapidly inhibits transcription, translation and DNA synthesis in sensitive cells but not insensitive cells. The acute transcriptional response to SW044248 correlates with the response to agents that cause DNA damage.Cell Research(from reference)Cell lines：NSCLC cell lines Incubation Time：96 h