Description
InformationSGC707 SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 ( PRMT3 ) with IC50 and K d of 31 nM and 53 nM, respectively.TargetsPRMT3 ; PRMT3 31 nM; 53 nM(Kd)In vitroIn cells, SGC707 binds to PRMT3 and reduces PRMT3-dependent H4R3me2a. SGC707 also stabilizes PRMT3 in both HEK293 and A549 cells with EC50 values of 1.3 µM and 1.6 µM, respectively.In vivoIn CD-1 male mice, SGC707 (30 mg/kg, i.p.) gives good plasma exposure over 6 h with the peak plasma level of 38000 nM, which suggests that SGC707 is suitable for animal studies.Cell Research(from reference)Cell lines：293, LnCap, U2O s, HFF, MCF-7, and MDA-MB-231 cells Concentrations：100 µM Incubation Time：72 h