Description
InformationPeficitinib (ASP015K, JNJ-54781532) is an orally bioavailableJAKinhibitor. Phase 3.TargetsJAKIn vitroASP015K suppresses the IL-2-induced proliferation of human T cells with greater potency than EPO-induced proliferation of human erythroleukemia cells. In human whole blood, ASP015K inhibits STAT5 phosphorylation (pSTAT5).In vivoIn the rat AIA model, ASP015K (p.o.) significantly decreases paw swelling and ankle bone destruction score