Description
InformationMAK683 MAK683 (EED inhibitor-1, example 2) is an inhibitor of embryonic ectoderm development (EED). MAK683 exhibits IC50 of 59 nM, 89 nM and 26 nM in EED Alphascreen binding, LC-MS and ELISA assay, respectively.TargetsEED (ELISA assay); EED (EED Alphascreen binding assay); EED (LC-MS assay) 26 nM; 59 nM; 89 nMIn vitroMAK-683 binds to EED and disrupts the PRC2 complex. Cell viability is not significantly affected and the levels of H3K27me3 are decreased. A significant increase in the percentage of mature PCs after MAK-683 treatment in association with a higher CD38 expression is also identified.Cell Research(from reference)Cell lines：MBCs Concentrations：2\u2009µM Incubation Time：4 days, 3 days