Description
IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. IR415 selectively interacts with HBx ( K d =2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease HBx: hepatitis B virus X protein.In VitroHepatitis B virus X protein (HBx) as a suppressor of host defenses consisting of RNAi-based silencing of viral genes. IR415 (50-200 µM) has a dose-dependent inhibitory effect on HBx, with a minimal effective concentration of 50 µM in HepG2/GFP-shRNA line transfected with HBx. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Kd: 2 nM (IR415-HBx interaction)