Gefitinib-based PROTAC 3 from Aladdin Scientific

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Gefitinib-based PROTAC 3

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Description

Product IntroductionGefitinib-based PROTAC 3 which conjugates an EGFR binding element to a VHL ligand via a linker induces degradation of EGFR and mutants with DC50 of 11.7 nM and 22.3 nM in HCC827(Exon 19 del) and H3255 (L858R) cells, respectively