Description
EP1013 (F1013) is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetesIn VivoEP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg EP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversal\nrate for this group is not significantly different from the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function. MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:Caspase