Description
NSC689857 is a potent EGFR and SCF SKP2 inhibitor with an IC 50 value of 36 µM for Skp2-Cks1. NSC689857 can inhibit p27 ubiquitylation (IC 50 =30 µM). NSC689857 has varied activity across cancer types, with more activity against leukemia cell lines than othersForm:SolidIC50& Target:IC 50 : 36 µM (Skp2-Cks1), 30 µM (p27 ubiquitylation)