Description
InformationAMG319 is a potent and selectivePI3Kδinhibitor withIC50of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.TargetsPI3Kδ ; PI3Kγ 18 nM; 850 nMIn vitroAMG319 inhibits anti-IgM/CD40L-induced B cell proliferation with IC50 of 8.6 nM and reduces pAkt level with IC50 of 1.5 nM. AMG319 also inhibits anti-IgD-induce CD-69 expression in HWB.In vivoIn female Lewis rats, AMG319 (3 mg/kg, p.o.) inhibits the KLH-induced inflammatory response by 88%. In the transgenic (IgMm) mice, AMG319 (, p.o.) inhibits in vivo pAKT with IC50 of 1.9 nM.Cell Research(from reference)Cell lines：PBMCs Incubation Time：72 h