Description
HOIPIN-1 (JTP-0819958) is a selective inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC 50=2.8) µ M) It can inhibit NF-kB activation mediated by LUBAC in vitroInformation：HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a linear ubiquitin chain assembly complex (LUBAC) inhibitor with IC50 of 2.8 µM. HOIPIN-1 specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway