Description
InformationFLLL32 is a potentJAK2/STAT3inhibitor withIC50of <5 µM. FLLL32 inhibits the induction of STAT3 phosphorylation byIFNαandIL-6in breast cancer cells.TargetsJAK2 <5 µMIn vitroIn MDA-MB-231 breast and PANC-1 pancreatic cancer cells, FLLL32 downregulates STAT3 phosphorylation and DNA-binding activity. In MDA-MB-231 cells, FLLL32 inhibit the formation of colonies and cell invasion. In human multiple myeloma, glioblastoma, liver cancer, and colorectal cancer cell lines, FLLL32 also leads to the inhibition of cell proliferation and the induction of caspase-3 and PARP cleavages.In vivoIn MDA-MB-231 xenografted mice, FLLL32 (50 mg/kg, i.p.) significantly reduces tumor burdens. In mouse xenografts with OS-33 osteosarcoma cells, FLLL32 (50 mg/kg, i.p.) also inhibits tumor growth by targeting STAT3.Cell Research(from reference)Cell lines：MDA-MB-231 cell line Concentrations：~5 µM Incubation Time：72 hours