Description
ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC 50 of 0.21 µM for ABHD17B. ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells.Appearance:SolidIC50& Target:IC50: 0.21 µM (ABHD17B)In Vitro:ABD957 (500 nM; pretreated for 1 h) attenuates N-Ras depalmitoylation in AML cells. ABD957 (0.11 nM-10 µM; 72 h) blocks the signaling and proliferation of NRAS-mutant leukemia cells. MCE has not independently confirmed the accuracy of these methBiological Activity:ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC 50 of 0.21 µM for ABHD17B. ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells