Description
DB008 is potent and selective PARP16 inhibitor with an IC 50 value of 0.27 µM, containing an acrylamide electrophilic reagent. DB008 is membrane-permeable and marks PARP16 selectively.Appearance:SolidIC50& Target:PARP16 0.27 µM (IC 50 )In Vitro:DB008 (0-1µM; 0-120 min; HEK 293T cells) covalently modifies Cys169 of PARP16 and exhibits excellent proteome-wide selectivity in the irreversible binding mode. DB008 (100 nM; 16 h; HAP1 WT and HAP1 PARP16 KO cells) rescues nutrient starvation-induceBiological Activity:DB008 is potent and selective PARP16 inhibitor with an IC 50 value of 0.27 µM, containing an acrylamide electrophilic reagent. DB008 is membrane-permeable and marks PARP16 selectively