Description
Application( R )-(+)-2-Methyl-CBS-oxazaborolidine solution [1M in toluene] may be used as a catalyst in the asymmetric borane reduction of perfluoroalkyl ketones. It may also be used in the preparation of: (-)-diospongin B (1 R )-2-azido-1-(2,2-dimethyl-4 H -1,3-benzodioxin-6-yl)ethanol ( S )-α-deuteriobenzyl alcohol (3 S,4 R,5 S )-1-(trimethylsilyl)-4,5-epoxyhex-1-yn-3-ol Excellent catalyst of asymmetric reductions. The CBS (Corey-Bakshi-Shibata) oxazaborolidine catalyst has been used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C 2 symmetrical ferrocenyl diols, and propargyl alcohols. Used in a desymmetrizing reduction leading to ( S )-4-hydroxycyclohexenone. CBS Catalysts for Asymmetric Reduction and Asymmetric Synthesis