Description
SAE/SUMO1 (Cell-free assay); SAE/SUMO2 (Cell-free assay) 3 nM; 11 nMIn vitroML-792 is a mechanism-based SUMO-activating enzyme (SAE) inhibitor with nanomolar potency in cellular assays. ML-792 selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation. Induction of the MYC oncogene increases the ML-792-mediated viability effect in cancer cells, thus indicating a potential application of SAE inhibitors in treating MYC-amplified tumors.Cell Research(from reference)Cell lines：HCT116 cells Concentrations：0.5 µM Incubation Time：48 h