Description
InformationWS6 is a β cell proliferation inducer via modulation ofErb3 binding protein-1 (EBP1)and theIκB kinasepathway.TargetsEBP1 ; IκB kinaseIn vitroWS6 induces R7T1 cell proliferation with EC50 of 0.28 µM, and promotes β cell proliferation in rodent and human primary islets. Both Erb3 binding protein-1 and the IκB kinase pathway are confirmed to function in the mechanism of action of WS6.In vivoIn RIP-DTA mouse model of β cell ablation, WS6 (50 mg/kg p.o.) ameliorates diabetes, and induces concomitant increases in β cell proliferation and β cell number.Cell Research(from reference)Cell lines：R7T1 cells Concentrations：~10 µM Incubation Time：4 days