Description
Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC 50 range of 0.1-0.5 µM Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against S. aureus 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 µg/mL, 1 µg/mL and 1 µg/mL, respectively Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparumIn VitroDose-response assays reveales Micrococcin P1 to be very potent with a minimal inhibitory concentration (MIC) of 32-63 nM. Cytotoxicity assays reveales no significant impairment on cell line growth (<10% inhibition at 30 mM) over a 40 h period for both the hepatic cell line HepG2 and the monocytic cell line THP-1, leading to a selectivity index greater than 500. Also investigats the intracellular activity of Micrococcin P1, it is active against GFP-expressing M. tuberculosis H37Rv growing inside RAW 264.7 macrophages with an IC 80 of about 1 mM with potency comparable with that of isoniazid. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:HCV,Bacterial,Parasite