Description
GSK-3 Inhibitor II is a potent inhibitor of GSK-3β (glycogen synthase kinase-3β) (IC:50:=390 nM). GSK-3 was first discovered to be involved in the control of glycogen metabolism, but has since been indicated in regulating a diverse range of cellular functions, such as neuronal cell survival and death. GSK-3β plays an important role in cardiomyopathies and has been shown to decrease MRP2 expression in neuronal growth factor (NGF)-induced PC-12 cells. Activation of GSK-3β plays a critical role in diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling