Description
InformationXD14 is an inhibitor of BET bromodomain with Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), respectively. XD14 also inhibits BRDT(1), CBP, p300 and BRDT(2) with Kd of 1.2 µM, 1.6 µM, 2.6 µM and 3.7 µM, respectively