Description
InformationPIK-294 is a highly selectivep110δinhibitor withIC50of 10 nM, 1000-, 49- and 16-fold less potent to PI3Kα/β/γ, respectively.In vitroPIK-294 shows distinct patterns of isoform selectivity to inhibit different subsets of class I PI3K isoforms (p110β, p110δ, and p110γ) and exhibits low sensitivity to p110α with IC50 of 10 µM). The m-phenol moiety of PIK-294 is able to penetrate the deep-affinity pocket of the ATP binding site, and thus increases in vitro inhibitory activity.In vivoCell Datacell lines：Concentrations：Incubation Time：Powder Purity:≥99%