Description
ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183 ) with an IC 50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC 50 =6.24 nM). ML401 shows good stability and no toxicityIn VitroML401 shows no toxicity (>50 µM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 µM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoML401 shows very good stability in both human plasma and mouse plasma. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 1.03 nM (EBI2)