Description
BCATc Inhibitor 2 is a selective branched-chain aminotransferase (BCAT) inhibitor for research of neurodegenerative diseases. The IC 50 s of 0.2 µM, 0.8 µM and 3.0 µM for rat cytosolic isoenzyme rBCATc, human cytosolic isoenzyme hBCATc and rat mitochondrial isoenzyme rBCATm, respectively. BCATc, also called BCAT1, is in the cytoplasmIn VitroBCATc Inhibitor 2 decreases calcium influx in neuronal cultures with an IC 50 =4.8±1.2 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoBCATc Inhibitor 2 also blocks calcium influx into neuronal cells following inhibition of glutamate uptake, and demonstrates neuroprotective efficacy in vivo. ?\nFollowing a 30 mg/kg subcutaneous injection to Lewis rats, BCATc Inhibitor 2 reaches a peak plasma concentration (Cmax) of 8.28 µg/mL at 0.5 h (t max ).? The mean plasma exposure (AUC) value is 19.9 µg h/mL, and the mean terminal half-life ranged from 12 to 15 h, indicating favorable PK parameters of BCATc Inhibitor 2. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 0.2 µM (rBCATc), 0.8 µM (hBCATc), 3.0 µM (rBCATm)