Description
Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC 50 s of 26 nM, 33 µM, and 1.8 µM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.In VitroFidarestat is an inhibitor of aldose reductase, with IC 50 s of 26 nM, 33 µM, and 1.8 µM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoFidarestat (SNK-860; 1 or 4 mg/kg. p.o., daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:IC50: 26 nM (Aldose reductase), 33 µM (AKR1B10), 1.8 µM (V301L AKR1B10)