Description
InformationSGC2085 SGC2085 is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) inhibitor with an IC50 value of 50 nM and >100-fold selective over other PRMTs.TargetsCARM1 (Cell-free assay) 50 nMIn vitroWith the exception of PRMT6 (IC50 = 5.2 µM), SGC2085 does not inhibit other PRMTs. Although CARM1(PRMT4) is previously shown to asymmetrically dimethylate BAF155 at R1064, no cellular activity is observed for SGC2085 when tested up to 10 µM. The absence of cellular activity for SGC2085 may due to poor permeability.Cell Research(from reference)Cell lines：HEK293 cells Concentrations：up to 10 µM Incubation Time：48 h