Description
InformationAS1517499 AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.TargetsSTAT6 (Cell-free assay) 21 nMIn vitroAS1517499 inhibit IL-4-induced Th2 differentiation of mouse spleen T cells, but has no influence on Th1 differentiation induced by IL-12. AS1517499 is able to prevent the IL-4-activated STAT6-mediated increase of the clonogenic potential of primary PCa cells. At a dose of 300\u2009nM, AS1517499 decreases the clonogenic potential of primary basal PCa cells.In vivoIn vivo treatment with AS1517499 ameliorates the antigen-induced bronchial smooth muscle (BSM) hyperresponsiveness by inhibiting the RhoA up-regulation in BSMs and, at least in part, by reducing the IL-13 production in the airways in mice. AS1517499 reduces preventive effects of apoptotic cell instillation on bleomycin-induced lung fibrosis by suppressing PPARγ.Cell Research(from reference)Cell lines：Normal human BSM cells Concentrations：100 nM Incubation Time：30 min