Description
(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent inhibitor of human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC 50 s of 10 nM and 68 nM, respectively. (Rac)-BMS-816336 has good metaboAppearance:SolidIC50& Target:IC50: 10 nM (Human 11β-HSD1) and 68 nM (Mouse 11β-HSD1)In Vivo:(Rac)-BMS-816336 (compound 6n) has good metabolic stability, and the remaining rates in human, mouse and rats of 88%,82% and 72%, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Biological Activity:(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent inhibitor of human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC 50 s of 10 nM and 68 nM, respectively. (Rac)-BMS-816336 has good metabo