Description
Alkaline hydrolysis of mevalonolactone gives mevalonate. Mevalonate is a precursor of farnesyl and geranylgeranyl pyrophosphates. These pyrophosphates are required for protein prenylation. Application(±)-Mevalonolactone is used to:• study the effect of statin on the prenylation of Ras and Rho GTPases• analyse the isoprenoid biosynthesis pathways in Listeria monocytogenes• study the the effects of statins on proliferation and migration of HUVECs (HGF-induced human umbilical vein endothelial cells)