Description
InformationUPF 1069 is a selectivePARP2inhibitor withIC50of 0.3 µM. It is ~27-fold selective against PARP1.In vitroUPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 µM while inhibiting PARP1 with IC50 of 8 µM.In vivoIn organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.Cell Datacell lines：Concentrations：Incubation Time：Powder Purity:≥99%