Description
BAY-805 is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymesIn VitroBAY-805 inhibits the activity of hUSP21 HTRF and hUSP21 Ub-Rhod with IC 50 values of 6 nM and 2 nM, respectively. BAY-805 (10 µM) induces the NF-κB activation with an EC 50 value of 17 nM. BAY-805 (10 µM and 50 µM) significantly inhibits the activity of USP21 and also shows weak influence on USP22 and USP10. BAY-805 (0.0001-1000000 nM) selectively inhibits the activity of USP21. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:USP21