Description
InformationAzacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.In vitroThe formation of Azacyclonol in human intestinal microsomes is linear with respect to time up to 60 min. The rates of formation of Azacyclonol increases linearly with microsomal protein concentration up to 2 mg/mL. The apparent Km and Vmax values of Azacyclonol are 0.82 µM and 60 pmol/min/mg protein in microsomes from human liver. The formation of Azacyclonol and terfenadine alcohol from terfenadine is confirmed to be catalyzed predominantly by CYP3A(4) isozyme, and the ratio of the rate of terfenadine alcohol formation to that of Azacyclonol is 3:1. The amount of Azacyclonol eliminated renally increases on average 2-fold after rifampin dosing.In vivoAzacyclonol (i.v.) impairs the response of the nictitating membrane to both post- and preganglionic stimulation. The activity of Azacyclonol in depressing transmission through the cat superior ceivical ganglion is 6.63%.Cell Datacell lines：HCT116 cells and HCT116 TP53-/- cellsConcentrations：Incubation Time：Powder Purity:≥99%