Description
A complex of polyene (pentaene) macrocyclic lactones antibiotics obtained from Streptomyces filipinensis. Filipin complex is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities. Filipin complex acts by binding cell membrane sterols, disrupting membrane integrity.inhibits mitochondrial respiration.Filipin III is the most abundant component of the bulk complex (>>70%) of the complex. In VitroFilipin complex (2 µg/ml; 1+48 h) inhibits PRRSV entry with respiratory syndrome virus (PRRSV) genome copies in infected cells reduced by 61% in MARC-145 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Macrolide