Description
SW2_152F is a potent, selective chromobox 2 chromodomain (CBX2 ChD) inhibitor with a K d of 80 nM. SW2_152F displays 24-1000-fold selectivity for CBX2 ChD over other CBX paralogs in vitro.Appearance:SolidIC50& Target:Kd: 80 nM (chromobox 2 chromodomain)In Vitro:SW2_152F inhibits CBX2 chromatin binding in cells, and blocks neuroendocrine differentiation of prostate cancer cell lines in response to androgen deprivation. MCE has not independently confirmed the accuracy of these methods. They are for referenceBiological Activity:SW2_152F is a potent, selective chromobox 2 chromodomain (CBX2 ChD) inhibitor with a K d of 80 nM. SW2_152F displays 24-1000-fold selectivity for CBX2 ChD over other CBX paralogs in vitro