Description
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT)Appearance:SolidIC50& Target:Cx43 HemichannelIn Vitro:Gap19 TFA (250 µM; for 30 min ) decreases mitochondrial potassium uptake. Gap19 TFA (400 µM) inhibits unitary hemichannel currents in HeLa-Cx43 cells. Gap19 TFA (100 µM) inhibits hemichannel unitary currents in ventricular cardiomyocytes. GIn Vivo:Gap19 TFA (iv; 25mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57/BL6 miceDosage:Biological Activity:Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT)