Description
InformationSC75741 SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. SC75741 efficiently blocks influenza virus propagation.TargetsNF-κB (Cell-based NF-κB reporter gene assay) 200 nM(EC50)In vitroSC75741 shows immunosuppressive activity by inhibiting human PBMC proliferation with IC50 of 2.2 µM. SC75741 inhibits replication of influenza A and B viruses by inhibiting NF-κB-mediated signalling on a transcriptional level. Moreover, SC75741 shows a high barrier for development of resistant virus variants.In vivoSC75741 (15 mg/kg i.p.) reduces virus replication and cytokine expression in mice lungs after H5N1 influenza virus infection.Cell Research(from reference)Cell lines：Human PBMCs Concentrations：~50 µM Incubation Time：48 hours