Description
AM281 is a selective CB1 receptor antagonist with an IC50 of 9.91 nM. AM281 inhibits CB2 receptor with an IC50 of 13000 nM。 Application：AM281 has been used as a cannabinoid 1 receptor antagonist:to study its effects on memory deficit following naloxone-precipitated morphine withdrawal in miceto study the role of CB1 receptor system in modulating acetaldehyde-induced effects in rats during the extinction-, relapse-, and conflict-experimentsto study its effect on scopolamine-induced memory deficit using object recognition paradigmto block synthetic cannabinoid (HU210)-induced analgesia in the ventrolateral orbital cortex (VLO) to evaluate the effect of CB1 receptors on the VLO modulation of pain