Description
PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.In VitroPCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor. PCO371 induces cAMP production with an EC 50 of 2.4 µM in COS-7 cells expressing hPTHR1, and 2.5 µM in COS-7 cells transfected with hPTHR1-delNT, and also enhances the phospholipase C activity (EC 50, 17 µM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:PTHR1