Description
MZP-54 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4, with a K d of 4 nM for Brd4 BD2. In VitroMZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a K d of 4 nM for Brd4 BD2. MZP-54 binds to VHL-EloC-EloB protein (VCB) with a K d of 105 ± 24 nM. MZP-54 shows an inhibitory activity against MV4;11 and HL60 cells, with pEC 50 s of 7.08 ± 0.05 and 6.37 ± 0.03, respectively. MZP-54 also exhibits high depletion of cMyc levels. MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:VHL BRD4 BD2 4 nM (Kd)