Description
InformationiFSP1 iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1/AIFM2) with EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout Pfa1 and HT1080 cells that overexpresses FSP1.TargetsFSP1/AIFM2 (Cell-free assay) 103 nM(EC50)In vitroiFSP1 selectively induces ferroptosis in GPX4-knockout Pfa1 and HT1080 cells that overexpressed FSP1. FSP1 is expressed in most tumour cell lines, and iFSP1 treatment robustly sensitizes these cells to RSL3-induced ferroptosis.Cell Research(from reference)Cell lines：human cancer cell lines (NCl-H1437, U-373, MDA-MB-436, SW620, MDA-MB-435S, A549, etc.) Concentrations：0.01 µM - 10 µM, 3 µM Incubation Time：24 h