Description
CB2R/FAAH modulator-3 (compound 27) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The K i values for CB2R/FAAH modulator-3 are 20.1 and 67.6 nM for CB2R and CB1R, respectively, and the IC 50 value for FAAH is 3.4 µM. CB2R/FAAH modulator-3 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infectionIn VitroCB2R/FAAH modulator-3 (compound 27)(10 µM) reduces the production of the pro-inflammatory cytokines TNFα, IFN-γ, IL-1β and IL6 in unstimulated monocytes and macrophages. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:CB1 67.6 nM (Ki) CB2 20.1 nM (Ki)