Description
InformationFF-10101 FF-10101 is a novel irreversible FLT3 inhibitor with ic50 of 0.20 nM and 0.16 nM for FLT3 (WT) and FLT3(D835Y), respectively.TargetsFLT3 (D835Y) (Cell-free assay); FLT3 (WT) (Cell-free assay) 0.16 nM; 0.20 nMIn vitroFF-10101 potently and selectively inhibits the growth of mutant FLT3-expressing leukemia cells in vitro.In vivoOral administration of FF-10101 shows significant anti-leukemic effects at 5 mg/kg and 10 mg/kg twice daily for 11 days in the PDX model of AML cells with FLT3-ITD.Cell Research(from reference)Cell lines：HEK293T cells Incubation Time：1 h