Description
InformationUBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 µM,induces a time-dependent activation of autophagy in several human tumor cell lines.TargetsSIRT6 (Cell-free assay) 38 µM(EC50)In vitroUBCS039 induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells.UBCS039 leads to autophagosome accumulation and induces autophagic flux in human cancer cells.UBCS039 also induces autophagy-associated cell death.Cell Research(from reference)Cell lines：HeLa cells Concentrations：100\u2009µM Incubation Time：24\u2009h