Description
DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC 50 of 0.60 µM for rat TrxR1. DVD-445 has good anticancer applicationIn VitroDVD-445 (Compound 7) shows a cytotoxic effect in SH-SY5Y, U87, HaCaT cell lines and PBMCs with IC 50 s of 10.99 µM, 9.70 µM, 8.30 µM, 55.71 µM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 0.60 µM (rat TrxR1)