Description
InformationFDI-6 FDI-6 (NCGC00099374) is an inhibitor of the Forkhead box protein M1 transcription factor (FOXM1) with IC50 of 22.5 µM.TargetsFOXM1 (Cell-free assay) 22.5 µMIn vitroFDI-6 (NCGC00099374) is characterized in depth and is shown to bind directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induces concomitant transcriptional down-regulation. Global transcript profiling of MCF-7 cells by RNA-seq shows that FDI-6 specifically down-regulates FOXM1-activated genes with FOXM1 occupancy confirmed by ChIP-seq.In vivoInhibiting FOXM1 with FDI-6 inhibits liver cancer cell growth in vivo.Cell Research(from reference)Cell lines：MCF-7 cells Concentrations：20 µM, 40 µM Incubation Time：6 h