Description
PTP inhibitor V, PHPS1 is a cell-permeable phosphotyrosine analogue, which can be used as a reversible, active site as a target, and a Shp-2 inhibitor that competes with the substrate (IC : 50 : and K : i : = 2.1 and 0.73 µM). PHPS1 inhibits ECPTP, PTP1B, Shp1, Mycobacterium MptpA only at higher concentrations (IC : 50 : 5.4, 19, 30, and 39 µM, respectively), and even almost none against PTPH1, STEP, PTPN7, PTPRK, GLEPP1 or LAR2 active. Concentrations up to 50 µM. PTP inhibitor V, PHPS1 has been shown to inhibit Shp-2-dependent cell signal transduction and tumor cell colony formation